Possible Interaction: Albumin and Dimethyl Sulfoxide

“ Dimethyl sulfoxide treatment altered the expression of genes involved in lipid (FAS, ACC1, ACC2, DGAT1, DGAT2, SCD) and glucose (PEPCK, G6Pase) metabolism as well as liver functionality ( albumin , alpha‐1‐antitrypsin, AFP).”

“ DMSO treatment also led to increases in heme content and the synthesis of haptoglobin, while it decreased the synthesis of albumin and AFP.”

“For the differentiation of FLCs into mature hepatocytes, DMSO added to the differentiation medium remarkably enhanced albumin secretion in the 3-D and monolayer cultures, although HGF was effective only in the monolayer culture.”

“Although OSM alone had very weak effects on hepatocyte functions, albumin secretion and cytochrome P450IA1/2 capacity were greatly enhanced when combined with NA or DMSO.”

“In DMSO treatment, albumin levels were higher than in the nontreated cells at all days studied.”

“This late albuminuria did not occur after injection of F(ab')2 fragments of the antibody, could be prevented by leukocyte depletion, and was greatly reduced by treatment with dimethylsulfoxide , a scavenger of hydroxyl radicals.”

“When DMSO was removed for greater than 48 h, the cells flattened and spread out, chords of cells were no longer well defined, albumin mRNA levels decreased, and fibronectin, β1 integrin, and TGFβ transcripts increased.”

“Studies of hepatocyte functional activity indicate that, during early culture, total cellular export protein synthesis, specific albumin synthesis, and glycogen synthesis are enhanced in the presence of DMSO.”

“ DMSO produced a dose-dependent reduction in final population density, reduced or eliminated cell piling and stimulated synthesis of albumin.”