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Last Updated: 2 years ago

Possible Interaction: Albumin and Diazepam



Research Papers that Mention the Interaction

On the other hand, binding parameters of DZ to bovine, rabbit and rat albumins were apparently different from those of human albumin.
Pharmaceutical Research  •  2004  |  View Paper
Albumin binding experiments after in vitro homocysteinylation show that homocysteinylated albumin is significantly altered at the diazepam , but not at the warfarin and salicilic acid binding sites.
Clinical chemistry and laboratory medicine  •  2007  |  View Paper
Flow microcalorimetry data demonstrated a decrease in the ability of uraemic albumin to bind octanoate, phenol red, salicylic acid, warfarin and diazepam.
Nephron Physiology  •  2003  |  View Paper
Hydrolysis and covalent binding were associated with the site II binding domain on albumin , because only diazepam inhibited these reactions.
Drug metabolism and disposition: the biological fate of chemicals  •  1997  |  View Paper
Diazepam induced a distant accommodation of the protein, an effect accompanied by an enhanced inhibition of the release of protons from albumin.
The influence of diazepam on the interaction was also investigated using the same techniques, suggesting that diazepam increases the association of tenoxicam to albumin.
The Journal of pharmacy and pharmacology  •  1993  |  View Paper
PROB and DIAZ at five times the molar albumin concentration also caused a decrease in CEF affinity from 4.5 x 10(4) M-1 (control) to 0.45 x 10(4) (PROB) and 3.0 x 10(4) (DIAZ) M-1 in isolated human serum albumin.
Biochemical pharmacology  •  1990  |  View Paper
The binding of diazepam to albumin was inhibited in a competitive manner and was not related to the anaesthetic potency of the vapours.
British journal of anaesthesia  •  1984  |  View Paper
L-Tryptophan and diazepam were found to compete for a common high-affinity binding site on albumin.
The Biochemical journal  •  1983  |  View Paper
It was demonstrated that the N-B transition of albumin is involved in the pH dependent binding of diazepam.
Biochimica et biophysica acta  •  1980  |  View Paper
In contrast, palmitic acid at ratios of desmethyldiazepam > oxazepam), and both metabolites reduced diazepam binding to albumin.
Biochemical pharmacology  •  1979  |  View Paper
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