Possible Interaction: Albumin and Dextran

“A decrease …−1 after albumin infusion … of dextran caused a substantial increase in the renal clearance (from 84 to 123 ml·min−1), non-renal clearance (from 72 to … of distribution (from 13 to 23 l) of frusemide, probably as a consequence of an increase in the unbound fraction.”

“We have previously shown that an addition of dextran to surfactant increases resistance to inactivation by albumin.”

“ Albumin was used as a control of the volume-expanding effect of dextran.”

“Significant reductions in that complication by albumin were also shown in subgroup analyses versus each of the other volume expanders tested (e.g., dextran , gelatin, hydroxyethyl starch, and hypertonic saline).”

“ Albumin reduced viscosity and aggregation, but especially dextran 75 increased both parameters significantly.”

“The steric repulsion conferred by the presence of DEX at the surface of the nanoparticles decreased the adsorption of albumin.”

“We hypothesized that albumin would decrease the hydraulic permeability (Lp) of isotonic and hypertonic solutions containing Dextran.”

“Indeed, dextran in the bath stimulated fluid absorption by 55% over albumin.”

“The minimum surface tension of 2.0 mg/ml MNS with 30 mg/ml albumin decreased from over 21 mN/m to below 3 mN/m when dextran was added at a concentration of 10 mg/ml (P < 0.01).”

“The surface adsorption time of 0.5 mg/ml modified natural surfactant (MNS; porcine lung extract consisting of phospholipids and hydrophobic surfactant proteins) with 7.5 mg/ml albumin decreased from 681 to 143 s by addition of dextran at a concentration of 10 mg/ml (P < 0.01).”

“The results suggest that isovolemic hemodilution with both albumin and dextran is associated with a marked increase in blood flow in the rabbit.”