Possible Interaction: Albumin and Cyclosporine

“A significant reduction of proteinuria and an increase of plasma albumin concentration was observed with treatment with cyclosporin.”

“Hematocrit (HCT), plasma albumin ALB ) level, and coadministration of itraconazole (ITR) were found to significantly affect the clearance of CsA (CL, L/h).”

“Conclusions Our results suggest that inhibition of hepatic albumin synthesis by high dose CsA contributes to the hypoalbuminemia in renal transplant recipients.”

“In contrast, CSA caused only a slight decrease in albumin levels (P < 0.05).”

“A weak, but significant, covariation was observed between the serum concentration of albumin or bilirubin and the free fraction of CyA (r = −0.47 and r = 0.39, respectively; p < 0.01).”

“A … with CsA … albumin excretion by almost 50% (from 336 +/- 91 to 178 +/- 58 mg/24 h; p = 0.002) and induced an increase in the serum … 7.1 +/- 4.1 to 12.8 +/- 3.2 mg/ml; p = 0.002) in contrast to the vehicle olive oil (OO).”

“These experiments suggest that the antiproteinuric effect of CsA is not (only) due to a decrease in the GFR, but also to a decrease of the enhanced permeability of the glomerular capillary wall for albumin.”

“Therapeutically administered dexamethasone (Dex) (0.1-1 mg/kg body weight) or cyclosporin A (CsA) (25-75 mg/kg body weight) dose-dependently reduced albumin movement across the blood-brain barrier (BBB).”

“Plasma magnesium and albumin were significantly lower in rats dosed with ciclosporin (40, 50 or 80 mg/kg) after 14 days.”

“ CsA induced an upsurge in the alanine transaminase, aspartate transaminase, and alkaline phosphatase levels and decreased albumin and total protein levels, expression of superoxide dismutase (SOD) gene, serum testosterone, triiodothyronine, and thyroxine levels compared to the control group.”