Possible Interaction: Albumin and Copper

“The … albumin in the … of incoming copper is well documented (Owen, 1965 and 1971; Marceau and Aspin, 1971; Campbell et al., 1981; Gordon et al., 1987), and albumin … long been known to carry a high affinity copper binding site at its N-terminus (Breslow, 1964; Lau and Sarkar, 1971).”

“ Albumin markedly inhibits copper uptake by a substrate removal mechanism, and histidine facilitates albumin-inhibited copper uptake.”

“ Ionic copper entering blood plasma binds tightly to albumin and the macroglobulin transcuprein.”

“This is the first to demonstrate that copper induces a covalent binding of FITC-labeled molecules with albumin.”

“The presence of albumin , contrary to urea, accelerates copper corrosion.”

“Mishandling of Cu by albumin contributes to oxidative stress in preeclampsia.”

“ Albumin significantly reduced the stimulation effect of copper , but not that of iron.”

“In the presence of albumin , cytotoxic effects of copper on erythrocytes in vitro were reduced.”

“Of the 23 amino acids that are known to be in human serum, a substantial number were shown (in physiological concentrations) to compete effectively with albumin for the binding of copper.”

“Increasing Cu improved total protein (TP) and albumin (ALB) (quadratic, P < 0.05).”