Possible Interaction: Albumin and Colchicine

“UNLABELLED Patients with alcoholic chronic liver disease when treated with colchicine during a 12 month-period improved significantly the plasmatic levels of albumin and prothrombin when compared with a similar group of patients who took placebo.”

“These findings suggest that albumin transport from the Golgi apparatus to sinusoids is disturbed by colchicine.”

“The results obtained indicated the following: (a) the transport and processing of polymeric IgA receptor is strongly inhibited and delayed, but the appearance of …) newly synthesized albumin secreted directly from hepatocytes in control and in colchicine‐treated animals is the major source of bile albumin; and (f) colchicine … albumin …. (”

“Secretion of [14C]leucine-labeled albumin and [3H]glucosamine-labeled glycoproteins was only minimally impaired (20%) by colchicine (50 microM) on gestation day 19.”

“ Colchicine (10 microM) impaired the secretion of immunoprecipitable albumin to about the same degree as trichloroacetic acid-precipitable proteins in both adult and fetus.”

“With this method, it has been determined that within 2 min of the administration of colchicine there is a noticeable reduction in the rate at which radioactive albumin is secreted into the blood.”

“In the presence of colchicine the secretion of both alpha 1-antitrypsin and albumin was impaired.”

“ Colchicine is a general inhibitor of in vivo secretion, as it inhibits the secretion of albumin , and that of other plasma proteins produced by the liver.”

“ Colchicine delayed the discharge of radioactive albumin from these filled secretory vesicles and caused an accumulation of both proalbumin and serum albumin within these cell fractions.”

“ Colchicine has been shown rapidly to block the secretion of serum proteins, including VLDL [l-4] and albumin [4].”