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Developmental pharmacology and therapeutics • 1983 | View Paper
“This effect was most pronounced with the compounds which had the highest degree of protein binding, such as cloxacillin , cephazolin, methacycline and sulfisoxazole, all of which are bound greater than 80% by albumin.”
“The high affinity of cloxacillin for albumin seriously interfered with the electrophoretic separation of the antibiotics and the quantitation of cloxacillin.”