Possible Interaction: Albumin and Cisplatin

“On the other hand, CDDP significantly increased the levels of urea and creatinine and decreased the levels of albumin and total protein.”

“Both isomers of diamminedichloroplatinum(II) bind to albumin and induce the formation of the albumin dimer (MW approximately 140 kDa).”

“During the later stages of reactions of cisplatin with albumin , release of NH3 occurs due to the strong trans influence of Met sulfur, which weakens the Pt-NH3 bonds, and protein cross-linking is observed.”

“Reactions of cisplatin (cis-[PtCl2(NH3)2]) with albumin are thought to play an important role in the metabolism of this anticancer drug.”

“ Cisplatin protein binding significantly correlated with albumin concentrations at 3.3, 8, and 24 hours (P < .01).”

“Thus, [PtCl2(1)], like cisplatin , reacts irreversibly with albumin through a solvent-assisted SN2 substitution pathway.”

“Reaction of albumin with cis-DDP resulted in incorporation of about 1 mol platinum per mol protein, and this platinum modified the single cysteine (Cys-34) in the molecule.”

“In contrast, albumin and creatinine clearance was significantly reduced in CP treated group.”

“ Se@Albumin NPs significantly improve intestinal mucositis induced with cisplatin ( CDDP ) in a mouse model via attenuating the level of intestinal oxidative stress, reducing intestinal permeability, and relieving gastric dysmotility.”

“In conclusion, cisplatin and oxaliplatin bind irreversibly with albumin in plasma and may irreversibly interact with tissue protein and/or DNA.”

“Interesting, the expression of D site of the albumin promoter binding protein (Dbp), a gene involved in detoxification and drug metabolism, was consistently suppressed in the liver, heart and kidney after cisplatin treatment, implying a role of DBP in the toxicity of cisplatin.”