Possible Interaction: Albumin and Captopril

“CONCLUSIONS Ca topril therapy si gnificantly impeded progression to clinical proteinuria and prevented the increase in alb umin ex cretion rate in nonhypertensive patients with insulin-dependent diabetes mellitus and persistent microalbuminuria.”

“ Albumin excretion rate decreased significantly during captopril therapy (baseline 78 +/- 114 micrograms/min; mean of monthly measurements 38 +/- 55 micrograms/min vs placebo 78 +/- 140 micrograms/min; p less than 0.001).”

“In vitro and in vivo, captopril formed disulfide bonds with albumin and other proteins.”

“Treatment with either captopril , enalapril or lisinopril reduced albumin excretion rate in comparison with control patients.”

“Treatment with either captopril , enalapril or lisinopril reduced albumin excretion rate in comparison with control patients.”

“Treatment with either captopril , enalapril or lisinopril reduced albumin excretion rate in comparison with control patients.”

“In contrast, captopril rapidly associates with albumin to form noncovalent albumin-captopril complexes.”

“ Captopril treatment equally attenuated cerebral herniation and hematoma expansion but was less effective in stopping albumin extravasation and allowed cerebrum volume to increase to post-stroke levels after 60 days of treatment.”

“The combination of irbesartan and captopril induced further reductions in blood pressure (140+/-3 mmHg) and albumin excretion rates (4.0x//1.5 mg/day).”