Possible Interaction: Albumin and Bosentan

“ET‐… albumin extravasation by 119 and 93% in the left ventricle and right atrium, … extravascular accumulation of Evans blue dye 5 Pretreatment of the animals with bosentan (10 mg kg−1) inhibited by 71 and 90% the depressor … (1 nmol kg−1) and the accompanying tachycardia and bradycardia, respectively.”

“… albumin extravasation was … by bosentan (10 mg kg−1) both in the left ventricle and right atrium, compared to the 86% inhibition observed with FR 139317 (2.… kg−1) 6 Like ET‐1, the ETB receptor‐selective agonist, IRL 1620 (0.3 and 1 nmol kg−1, i.v.)”