Possible Interaction: Albumin and Aspirin

“In contrast, albumin enhanced the enzyme‐catalysed hydrolysis of aspirin.”

“We adjusted for ASA classification, which had a negative confounding effect on the predictive power of the percent drop in albumin to adverse outcomes.”

“The analysis of (1)HNMR spectral parameters i.e. changes of chemical shifts and relaxation times of the drug indicate that the presence of ASA weakens the interaction of PBZ with albumin.”

“These early-activated platelet profiles were significantly inhibited in albuminuric patients with aspirin intake, although the effect was incomplete.”

“Moreover, 12-HETE production in the presence of albumin was markedly increased and prolonged after aspirin treatment.”

“The rate of acetylation of albumin by aspirin at 37 degrees C and pH = 7.30 was found to proceed two orders of magnitude faster than the glycosylation, providing a basis for therapeutic possibilities for the complications of diabetes mellitus.”

“Acetylation of the lysine-199 residue with aspirin and 5-nitroaspirin decreased the trinitrophenylation rate of albumin with I. These results on the fluorescence spectroscopy and the effect of the acetylation suggest that the reactive group for I is the lysine-199 residue located near the tryptophan-214 residue.”

“Plasma proteins, in particular albumin or a contaminant of the albumin fraction tested, enhance the inhibitory effect of aspirin on platelet aggregation.”

“In addition, ASA apparently displaces SA from its binding sites on albumin , an observation that may have therapeutic implications.”

“The administration of ASA significantly inhibited venule leakage of albumin and reduced increases in interstitial pressure after treatment.”