“ESCHERICHIA COLI L-asparaginase, an antileukemic agent, acts by hydrolyzing plasma L-asparagine to L-… effects lack asparagine synthetase and thus require exogenous asparagine for growth.3 Administration of L-asparaginase … albumin , cholesterol, insulin, fibrinogen and various clotting factors.2 , 4 … thyroid-function studies in patients receiving L-asparaginase.”