Possible Interaction: Albumin and Arachidonic Acid

“ Albumin also effectively binds arachidonic acid (AA), which increases capillary permeability.”

“Both types of albumin inhibited the conversion of arachidonic acid to prostaglandin H2 in a dose-dependent manner without affecting phospholipase A2 or prostacyclin synthetase.”

“Platelet aggregation induced by arachidonic acid was inhibited by adenosine, β naphthol, non-steroidal anti-inflammatory agents, unsaturated fatty acids and albumin.”

“[Ca2+]i oscillations could be induced by low lipid albumin with arachidonic acid added.”

“In the presence of physiological concentrations of albumin , the metabolism of both 12-HETE and arachidonic acid was substantially altered, implicating the importance fatty acid binding proteins might have on the profile of products formed both in vitro and in vivo.”

“These studies indicate that albumin enhances liberation of arachidonic acid from phospholipids but has an overall inhibitory effect on thromboxane synthesis.”

“The effect of octanoic acid and arachidonic acid on ChAT activity appeared to increase in the presence of albumin.”

“Mixtures of albumin with PA or AA actually had a reduced inhibitory effect on LS and CLSE activity compared with the free fatty acids alone, apparently because of albumin binding of these molecules.”

“In the presence of albumin (1–10 mg/ml), a free fatty acid‐binding protein, inhibition by either melittin, thimerosal, or arachidonic acid is prevented and an enhancement of glutamate uptake above the control levels is observed.”

“ Albumin clearance was also greater (P < 0.05) in lungs that received AA.”