Possible Interaction: Albumin and Anti-Inflammatory Agents, Non-Steroidal

“ Non-steroidal anti-inflammatory drugs like … albumin at low concentrations (EC50 10−4–10−5 mol/l) comparable to those active in a classical turbidimetric method, whereas the … formic, fumaric, maleic, malonic, and succinic acid (EC50 10−1–10−2 mol/l in the Mizushima test) was not detectable.”

“Other widely used nonsteroidal antiinflammatory drugs like tolmetin, ibuprofen, and naproxen are also strongly bound to albumin and can potentially displace phenytoin.”

“The nonsteroidal antiinflammatory drugs mefenamic acid and fenoprofen are also strongly bound to albumin.”

“These findings are explained by association and dissociation of NSAIDs and albumin that occur far more rapidly than vascular transit.”

“The NSAIDs are highly bound to plasma proteins (mainly albumin ), which limits their body distribution to the extracellular spaces.”

“Initial brain uptake for all three NSAIDs was reduced by the addition of albumin to the perfusion buffer.”

“CONCLUSIONS: Transtympanic steroid reduced LPS induced middle ear effusion while NSAID reduced albumin concentration in the rat model.”

“However, subsequently (post 5hr) albumin concentration in the pouch rises sufficiently to lower the effective flux of the NSAIDs.”

“Both NSAIDs induced the recruitment of adherent and emigrated leukocytes with temporally related increases in albumin leakage.”