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Discover Supplement-Drug Interactions

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Last Updated: 2 years ago

Possible Interaction: Albumin and Anti-Inflammatory Agents, Non-Steroidal

Research Papers that Mention the Interaction

Non-steroidal anti-inflammatory drugs like … albumin at low concentrations (EC50 10−4–10−5 mol/l) comparable to those active in a classical turbidimetric method, whereas the … formic, fumaric, maleic, malonic, and succinic acid (EC50 10−1–10−2 mol/l in the Mizushima test) was not detectable.
Clinical chemistry and laboratory medicine  •  1998  |  View Paper
Other widely used nonsteroidal antiinflammatory drugs like tolmetin, ibuprofen, and naproxen are also strongly bound to albumin and can potentially displace phenytoin.
Therapeutic drug monitoring  •  1996  |  View Paper
The nonsteroidal antiinflammatory drugs mefenamic acid and fenoprofen are also strongly bound to albumin.
Therapeutic drug monitoring  •  1996  |  View Paper
These findings are explained by association and dissociation of NSAIDs and albumin that occur far more rapidly than vascular transit.
Clinical pharmacokinetics  •  1993  |  View Paper
The NSAIDs are highly bound to plasma proteins (mainly albumin ), which limits their body distribution to the extracellular spaces.
Clinical pharmacokinetics  •  1983  |  View Paper
Initial brain uptake for all three NSAIDs was reduced by the addition of albumin to the perfusion buffer.
Pharmaceutical Research  •  2006  |  View Paper
CONCLUSIONS: Transtympanic steroid reduced LPS induced middle ear effusion while NSAID reduced albumin concentration in the rat model.
Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery  •  2006  |  View Paper
However, subsequently (post 5hr) albumin concentration in the pouch rises sufficiently to lower the effective flux of the NSAIDs.
Pharmaceutical Research  •  2004  |  View Paper
Both NSAIDs induced the recruitment of adherent and emigrated leukocytes with temporally related increases in albumin leakage.
The American journal of physiology  •  1996  |  View Paper