Possible Interaction: Albumin and Aldesleukin

“This strategy, first reported by Patrice Yeh et al. in 1992 (8), … confer at least some of the stability and plasma longevity of albumin onto smaller fusion partners, … thrombin inhibitor hirudin (9), interleukin 2 (10), brain natriuretic peptide (11), and interferon α-… being in phase 3 clinical trials (12).”

“administration when RIL-2 was injected with a high concentration (12.5%) of human albumin , which acts as a retarder and a promoter of lymphatic absorption.”

“Intrathecal levels of IL-2 and sIL-2R were significantly higher in MS compared with the control groups and correlated with albumin ratios in MS patients.”

“A significant correlation between albumin and concentration of the cytokines IL1β, IL2 , IL6, and TNFα was found (P<0.01), correlation coefficients (r) being 0.56, 0.56, 0.67, and 0.71 (n=418), respectively.”

“This mitogenic factor stimulated the synthesis of the negative acute‐phase plasma protein, albumin , and inhibited the synthesis of the positive one, α1‐antichymotrypsin, whereas it moderately influenced the synthesis of fibrinogen.”

“… albumin increased from 9.4 +/- 2.7% …% h-1 (P < 0.001) after IL-2 injections and the absolute outflux of albumin (Jalb) from 159 +/- 28 mg kg-1 h-1 to … (P < 0.001), whereas the intravascular albumin pool remained stable (136 +/- 19 g vs 136 +/- 18 g).”

“Our data show that when albumin is present, the plasma concentrations of interleukin-2 versus time is increased and swelling at the injection sites is reduced.”

“The mechanism of these effects is unknown, but the use of albumin with IL-2 should be carefully investigated in future studies.”

“Variable concentrations of albumin were added to the infusion of IL-2.”

“Compared to control cultures, 20 U of rIL-1 and 20 U of mIL-1 increased albumin transfer across endothelial monolayers 205% and 459%, respectively.”

“In particular, on matrices with high compliance, costimulatory aggregation is shown to elicit a marked increase in albumin secretion rate, whereas on matrices with low compliance aggregation results in effective functional repression to basal, unstimulated levels.”