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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Alanine
drug:
Valproic Acid
Research Papers that Mention the Interaction
“Also the concentrations of lactate, pyruvate, alanine and glycerol increased after valproate administration.”
Valproate causes metabolic disturbance in normal man.“N-dipropyl-acetate Depakine ) induces a hyperglycinuria and simultaneously an increase of urinary excretion of alanine and a decrease of serine, glutamate and/or glutamine, histidine and/or ornithine.”
“Concomitant administration of ALA and GLA with VPA demonstrated a marked cutdown in the Pgp 9.5 expression with GLA having more pronounced effect.”
Comparative efficacy of alpha-linolenic acid and gamma-linolenic acid to attenuate valproic acid-induced autism-like features“ Valproate markedly stimulated glutamine removal as well as … formation of ammonia, aspartate, pyruvate, lactate, alanine and glucose; the increase in ammonia formation was explained by a stimulation by valproate of flux not … through glutaminase (EC 3.5.1.2) but also through glutamate dehydrogenase (EC 1.4.1.3).”
“ Valproate strikingly reduced the renal cortical concentrations of glutamine, glutamate, alphaketoglutarate and citrate, and more modestly those of malate, oxaloacetate, aspartate, alanine and ATP.”
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