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Last Updated: 2 years ago

Possible Interaction: Alanine and Valproic Acid

supplement:

Alanine

Research Papers that Mention the Interaction

Also the concentrations of lactate, pyruvate, alanine and glycerol increased after valproate administration.
Journal of neurology, neurosurgery, and psychiatry  •  1986  |  View Paper
N-dipropyl-acetate Depakine ) induces a hyperglycinuria and simultaneously an increase of urinary excretion of alanine and a decrease of serine, glutamate and/or glutamine, histidine and/or ornithine.
Helvetica paediatrica acta  •  1978  |  View Paper
Concomitant administration of ALA and GLA with VPA demonstrated a marked cutdown in the Pgp 9.5 expression with GLA having more pronounced effect.
Journal of Physiology and Biochemistry  •  2016  |  View Paper
Valproate markedly stimulated glutamine removal as well as … formation of ammonia, aspartate, pyruvate, lactate, alanine and glucose; the increase in ammonia formation was explained by a stimulation by valproate of flux not … through glutaminase (EC 3.5.1.2) but also through glutamate dehydrogenase (EC 1.4.1.3).
Biochemical pharmacology  •  1989  |  View Paper
Valproate strikingly reduced the renal cortical concentrations of glutamine, glutamate, alphaketoglutarate and citrate, and more modestly those of malate, oxaloacetate, aspartate, alanine and ATP.
Kidney international  •  1988  |  View Paper