Possible Interaction: Alanine and Urea

“RESULTS Study I: Al nine in fusion increased ure a sy nthesis rate by a factor of 10 in the control subjects, and by a factor of 5 in the CP patients (P<0.01).”

“The urea synthesis rate during alanine infusion was still higher by approximately 30 mmol.h-1 in hyperthyroid subjects.”

“When alanine was infused over the final 2 hr of a second protocol, urea enrichment decreased significantly, indicating an increase in urea production from 4.4 +/- 0.31 to 7.0 +/- 0.63 mumol/kg X min.”

“With glucose plus urea , glutamic acid rose and fell, aspartic acid decreased slightly and alanine increased several fold.”

“ Urea favoured the formation of alanine perhaps by transamination or by direct amination of pyruvate involving different pathways.”

“The results indicated that exposure to 500 and 1000 mg kg−1 MPs caused a significant increase in the activities of alanine and aspartate aminotransferases, and in the levels of cholesterol, glucose, creatinine, urea , and calcium (Ca+2) compared with the control group.”

“At all enzyme activities, infusion of alanine resulted in a significant increase in the rate of urea production compared with controls (P < 0.001).”

“Infusion of alanine resulted in at least a threefold increase from baseline in the rate of calculated urea production, suggesting that neonatal piglets, small or large, have reserve capacity to metabolize nitrogen and excrete it as urea.”

“ Urea production was increased by alanine to a greater extent in the septic group compared to sham.”

“Surgery increased the concentration gradient (release) of urea across liver by 60%, the glucose gradient (release) by 35%, and doubled the concentration gradients (uptake) across liver of alanine , arginine, glycine, lysine, proline, serine, and threonine, and decreased their plasma concentrations.”