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Discover Supplement-Drug Interactions

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Last Updated: 3 years ago

Possible Interaction: Alanine and Tissue Plasminogen Activator

supplement:

Alanine

drug:

Tissue Plasminogen Activator

Research Papers that Mention the Interaction

“Mutation of threonine 1057 to alanine however caused partial regain of betagamma-stimulation in the presence of TPA by 40%, as compared to that of WT adenylyl cyclase type II which was 70% in the absence of TPA.”
Phorbol ester-induced sensitisation of adenylyl cyclase type II is related to phosphorylation of threonine 1057.
Biochemical and biophysical research communications  •  1997  |  View Paper
“The substitution of serine for alanine at position 473 substantially reduced the slow inactivation that occurs at pharmacological levels of t-PA in plasma.”
Substitution of serine or threonine at position 473 of tissue-type plasminogen activator increases its stability in plasma.
Thrombosis and haemostasis  •  1996  |  View Paper
“Within amino-terminal residues 1-114, alanine 103 and leucine 104 are required for inhibition of t-PA and alpha 2M* binding.”
Sites within the 39-kDa protein important for regulating ligand binding to the low-density lipoprotein receptor-related protein.
Biochemistry  •  1995  |  View Paper