Possible Interaction: Alanine and Threonine

“The substitutions of these threonines with alanines decreased Pax6 transactivation, whereas substitutions to glutamic acids increased transactivation in mimicry of phosphorylation.”

“Replacement of Thr with Ala at amino acid 366 or 367 caused a modest enhancement of K-RTA transactivation activity in a luciferase reporter assay and a cell model for KSHV reactivation.”

“Substitution of alanine for threonine at this position reduced early viral propagation, an effect apparently unrelated to NS1 antagonizing host interferon responses or activating phosphoinositide 3-kinase signaling.”

“Mutation of any one of these Ser or Thr residues to Ala caused reductions in the receptor phosphorylation state, the number and pattern of phosphopeptides observed in tryptic maps, and ANP-dependent guanylyl cyclase activity.”

“The replacement of threonine 334 with alanine resulted in a marked augmentation of catalytic activity.”

“Mutation of either threonine or tryptophan to alanine resulted in a lowering of the activity of the R*basal similar to the Rg.”

“Each substitution of threonine to alanine changes the energy barrier of the closing process by approximately 0.5 kcal/mol.”

“Substitution of the respective threonine by alanine in the rod photoreceptor and olfactory channels decreases the cGMP sensitivity of channel activation 30-fold but little affects activation by cAMP.”

“Substitution of alanine with the hydrophilic residue threonine at position 117 likely disrupts this hydrophobic channel and may decrease the availability of the catalytic site to substrates, thereby diminishing the catalytic efficiency of C57BL/6-derived catalase.”

“Furthermore L-alanine inhibits enzymic activities towards serine and threonine to different extent.”