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Discover Supplement-Drug Interactions
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Last Updated: 2 years ago
Research Papers that Mention the Interaction
“Substitution of proline by alanine at amino acid positions 639 and 641 within Box 1 completely abolished the G-CSF-mediated growth signal.”
Point mutations in the conserved box 1 region inactivate the human granulocyte colony-stimulating factor receptor for growth signal transduction and tyrosine phosphorylation of p75c-rel.“When these prolines were substituted with alanine , nuclear transport activity was reduced drastically in vivo and in vitro, and caused a severe defect in mitotic progression.”
“Although the functional significance of this polymorphism is unknown, we postulate that the substitution of proline , an α-imino acid, with alanine , an amino acid, could be of biochemical significance.”
“Nevertheless, highly helical alanine-based design peptides with anchor spacing i, i + 9 exhibit maximal affinity, whereas replacement of alanine by helix destabilizing proline abrogates binding.”
“Combined supplementation of maltodextrin, alanine , and proline induced higher blood glucose levels than isocaloric maltodextrin alone during the late exercise phase (100-170 min).”
Combined supplementation of carbohydrate, alanine, and proline is effective in maintaining blood glucose and increasing endurance performance during long-term exercise in mice.“Glycine, l-alanine , and l-tryptophan strongly inhibited l-proline uptake indicating that these amino acids also interact with the transport system.”
“Replacement of asparagine 5, proline 6, or histidine 12 with alanine resulted in >2700-fold, 700-fold, and approximately 2700-fold losses in toxin potency, respectively.”
“Only the substitution of alanine with proline reduced the GTPase activity by an order of magnitude.”
“Certain other amino acids (L-valine, L-alanine , L-methionine, L-phenylalanine, L-tryptophan and L-hydroxyproline) significantly stimulated proline uptake.”
“Replacement of the proline residue in position 7 with alanine reduced the pressor and vascular contractile response to less than 1 % of Ang II.”
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