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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Alanine
supplement:
Polyunsaturated Fatty Acids
Research Papers that Mention the Interaction
“Dietary ALA suppressed the concentration of n-6 LC PUFA in blood plasma by more than 50%.”
“The effect of ALA intake on n-3 LC PUFA was suppressed by LA intake.”
Effect of intake of linoleic acid and α-linolenic acid levels on conversion into long-chain polyunsaturated fatty acids in backfat and in intramuscular fat of growing pigs.“BackgroundDietary supplementation with botanical oils that contain n-6 and n-3 eighteen carbon chain (18C)-PUFA … acid (GLA, 18:3n-6), stearidonic acid (SDA, 18:4n-3) and α linolenic acid ALA , 18:3n-3) … to impact PUFA metabolism, alter inflammatory processes including …) metabolism and improve inflammatory disorders.”
Impact of botanical oils on polyunsaturated fatty acid metabolism and leukotriene generation in mild asthmatics“It was found, that more than 40% of studied subjects consumed daily less than 1 g ALA , about 50%--less than 100 mg LCn-3 PUFA and about 60% less than 10 mg DHA.”
“Altogether, the present data provide evidence that a diet supplemented with ALA increases the transport of lipids into resting skeletal muscle in conjunction with increased sarcolemmal n-3 PUFA and FAT/CD36 contents.”
“Rats fed a diet supplemented with ALA (10%) displayed marked increases in omega-3 polyunsaturated fatty acids (PUFAs) within whole muscle and sarcolemmal membranes (approximately five-fold), at the apparent expense of arachidonic acid (-50%).”
“… ALA increased …-3 LCPUFA , the activity and expression of desaturases, the antioxidative status, the expression and DNA-binding of PPAR-α, the oxidation of fatty acids and … antioxidant enzymes, whereas the expression and DNA-binding activity of SREBP-1c transcription factor and the biosynthetic activity of fatty acids declined.”
“ConclusionMaternal supplementation of ALA in normal and protein-restricted diets modulates n-3 PUFA levels, cholesterol, leptin levels and also adipose growth in the suckling offspring.”
“In conclusion, dietary LA and ALA have differential effects on renal oxylipins and PUFAs , and ALA-derived oxylipins are associated with renoprotection in this model of ORG.”
“Plasma ALA concentrations were higher in n-3 PUFA than control cows, following a linear relation with supplement ingestion, resulting in a lower n-6/n-3 ratio in plasma.”
Effects of feeding rumen-protected linseed fat to postpartum dairy cows on plasma n-3 polyunsaturated fatty acid concentrations and metabolic and reproductive parameters.“ LCPUFA parameters have shown to increase the risk in both conditions, particularly ALA ≤ 53 µmol/L in preeclampsia with OR 5.44, 95%CI 1.16–25.42 and preterm birth with OR 4.68, 95%CI 1.52–14.38.”
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