Allen Institute for Artificial Intelligence
supp.ai logo
supp.ai

Discover Supplement-Drug Interactions

Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 2 years ago

Possible Interaction: Alanine and Phosphatidylinositol 4,5-Diphosphate

Research Papers that Mention the Interaction

Replacement of amino acids K63,64 and K265,266 by alanine abolished the interaction of the membrane-binding domain with PIP2.
Biochemistry  •  2006  |  View Paper
In Kir2.1, mutation of one of these CD-I salt bridge … apparent PIP2 sensitivity of channel activity, and here we show that Ala or Cys substitutions of the functionally equivalent residue (Arg-165) in … channel KirBac1.1 also significantly decrease sensitivity of the channel to PIP2 (by …-fold).
The Journal of Biological Chemistry  •  2017  |  View Paper