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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Alanine
supplement:
Phosphatidylinositol 4,5-Diphosphate
Research Papers that Mention the Interaction
“Replacement of amino acids K63,64 and K265,266 by alanine abolished the interaction of the membrane-binding domain with PIP2.”
Phosphatidylinositol-4,5-biphosphate (PIP2) differentially regulates the interaction of human erythrocyte protein 4.1 (4.1R) with membrane proteins.“In Kir2.1, mutation of one of these CD-I salt bridge … apparent PIP2 sensitivity of channel activity, and here we show that Ala or Cys substitutions of the functionally equivalent residue (Arg-165) in … channel KirBac1.1 also significantly decrease sensitivity of the channel to PIP2 (by …-fold).”
Conformational changes at cytoplasmic intersubunit interactions control Kir channel gating
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