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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Alanine
drug:
Phenelzine
Research Papers that Mention the Interaction
“… phenelzine or PEH to rats has been reported … rat brain levels of GABA and alanine while reducing levels of glutamine; these effects are abolished for phenelzine, but not for PEH, when the … another MAO inhibitor, suggesting that they are mediated by the MAO-catalyzed formation of PEH from phenelzine.”
Elevation of rat brain tyrosine levels by phenelzine is mediated by its active metabolite β-phenylethylidenehydrazine“Both PEH isomers and phenelzine produced marked increases in rat brain levels of GABA and alanine while decreasing brain levels of glutamine.”
“Only PLZ inhibited MAO and ALA-T and elevated ALA levels.”
“Acetylation of phenelzine at the N2 position presumably interferes with the inhibition of the transaminase enzymes for γ-aminobutyric acid and alanine.”
“Acute administration of PLZ produces several neurochemical changes, including an increase in brain levels of the catecholamines norepinephrine (NE) and dopamine (DA), of 5-hydroxytryptamine (5-HT), and of the amino acids alanine and gamma-aminobutyric acid (GABA).”
“At a dose of phenelzine of 15 mg/kg IP, there was a significant increase in brain levels of alanine up to 16 hr after drug administration.”
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