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Discover Supplement-Drug Interactions
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Last Updated: 2 years ago
supplement:
Alanine
drug:
Naltrexone
Research Papers that Mention the Interaction
“Mutation of Asp147 to Ala or Asn substantially reduced the affinity of naltrexone and the affinity, potency and efficacy of morphine, while the Glu mutant had similar properties as the wildtype, indicating the significant role of the carboxylate group of Asp147 in receptor binding and activation.”
ASP147 in the third transmembrane helix of the rat mu opioid receptor forms ion-pairing with morphine and naltrexone.
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