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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
Research Papers that Mention the Interaction
“We also verified that alanine inhibited the in vitro activity of Complexes I + III by competition with NADH.”
Inhibition of the Mitochondrial Respiratory Chain by Alanine in Rat Cerebral Cortex“The mutation of Ser(99) to either alanine or valine, and of Arg(63) to either alanine or glutamine increased both the K(m) values for NADH (K(m)(NADH)) and the dissociation constant for NAD(+) (K(d)(NAD+)).”
“Moreover, the K167 to alanine mutation led to even a slight increase in k(cat)/K(m) for NADH.”
Structure-function relationship of Vibrio harveyi NADPH-flavin oxidoreductase FRP: essential residues Lys167 and Arg15 for NADPH binding.“ Alanine inhibited uncompetitively with respect to NADH (Ki=1.6 mM) and noncompetitively with respect to ammonia (Ki=2.0 mM) and pyruvate (Ki=3.0 mM).”
“Substitution of tryptophan 677 with alanine has been shown to yield a 3-fold increase in turnover with NADH , but profound inhibition by NADP+ makes the enzyme unsuitable for in vivo applications.”
“In the vesicles, remarkable activity of L-alanine uptake was demonstrated in the presence of NADH or ascorbate-phenazine methosulfate as an energy source.”
“ NADH strongly stimulated the uptake of aspartic acid and alanine by membrane vesicles but had only a slight effect on the uptake of histidine and lysine.”
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