Possible Interaction: Alanine and Methionine

“Mutations of the methionine (M) or threonine (T) to alanine (A) reduced the dominant positive effect, while mutation of the tyrosine (Y) to either A or phenylalanine (F) completely abolished the dominant positive effect.”

“Substituting all four methionines to alanine significantly reduced the formation of DA-mediated soluble oligomers.”

“Via alanine , isoleucine, L-serine dehydratase/L-threonine deaminase and other proteins, AgNP-cit altered the metabolism of glycine, serine and threonine, cysteine and methionine , affecting oxidation and deamination, and ultimately leading to liver damage.”

“Plasma alanine concentration was linearly increased as DLM or 2‐hydroxy‐4‐(methylthio) butanoic acid (HMTBA) supplementation level increased.”

“The substitution of methionine with glycine, threonine, or alanine caused a complete loss of the neotropic activity of the peptide.”

“A 20-fold excess of unlabeled leucine, isoleucine, methionine , valine, alanine, lysine, histidine, phenylalanine, and glutamine inhibited uptake of leucine and phenylalanine, and six of these amino acids inhibited uptake of alanine , by more than 50% both in the presence and absence of a potassium ion gradient.”

“ Methionine is an effective inhibitor of both Na‐independent uptake mechanisms for alanine.”

“Uptake of Leu and of Ala from the tetrapeptides was strongly inhibited by Met , as was uptake of these amino acids from free solution.”

“Kinetic studies showed that ethionine, norleucine, and alanine are also competitive inhibitors of methionine uptake.”

“l -Ethionine and l -norleucine, as well as a number of neutral, nonpolar amino acids (leucine, isoleucine, valine, and alanine ) also inhibit methionine uptake.”

“Other essential amino acids such as l-lysine, l-histidine, and l-methionine at 2 mM concentrations were also significantly inhibited by 40 mM l-Ala.”