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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
Research Papers that Mention the Interaction
“ Metformin triggers alanine production within the Sertoli cells (SCs,) balances the NADH/NAD+ equilibrium and provides antioxidant environment.”
Metformin, Oxidative Stress and Male Infertility: Way Forward.“We found that metformin impedes the hepatic conversion of redox-modulating substrates (lactate and glycerol), but not redox-neutral substrates ( alanine and pyruvate) into glucose,” says Shulman. “”
“ Metformin increases alanine levels and reduces the phospholipid content in very large HDL particles.”
“Combination of ALA (100 mg/kg, ip) with metformin (100 mg/kg, ip) exhibited a potentiating effect in improving cognitive performance and insulin signalling.”
Alpha lipoic acid and metformin alleviates experimentally induced insulin resistance and cognitive deficit by modulation of TLR2 signalling.“In contrast, metformin markedly reduced the rates of glucose production from lactate/pyruvate, alanine , dihydroxyacetone, and galactose.”
“In isolated hepatocytes from fasted rats, a significant inhibition of glucose production from lactate/pyruvate (10:1, mol/mol), fructose, alanine or glutamine, following metformin addition, is observed.”
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