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Last Updated: 2 years ago

Possible Interaction: Alanine and Kanamycin

supplement:

Alanine

Research Papers that Mention the Interaction

Functional studies confirmed that alanine treatment together with kanamycin could promote ROS production that in turn potentiates the killing of antibiotic-resistant bacteria.
Our previous study demonstrated that alanine or/and glucose increased the killing efficacy of kanamycin on antibiotic-resistant bacteria, whose action is through up-regulating TCA cycle, increasing proton motive force and enhancing antibiotic uptake.
Our results suggest a novel mechanism by which alanine facilitates kanamycin killing of antibiotic-resistant bacteria via promoting ROS production.
Front. Microbiol.  •  2018  |  View Paper