Allen Institute for Artificial Intelligence
supp.ai logo
supp.ai

Discover Supplement-Drug Interactions

Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 2 years ago

Possible Interaction: Alanine and Isoleucine

supplement:

Alanine

supplement:

Isoleucine

Research Papers that Mention the Interaction

We found that a … amino acid substitution of alanine by phenylalanine at … or lysine by isoleucine at H93, significantly reduced the binding affinity for the TAG72 antigen by 12 and 20-fold, respectively, whereas the substitution of lysine by alanine at H73 reduced the binding affinity only two-fold.
Journal of molecular biology  •  1995  |  View Paper
Thioflavin T assays indicate that substitution of isoleucine for alanine significantly reduces the rate and extent of fibrillization compared to the Aβ(25-40) and G37A peptides.
Biophysical chemistry  •  2017  |  View Paper
Following a careful analysis of known metabolic pathways we found that co-addition of perdeuterated forms of α-ketoisovalerate-d7, succinate-d4 and l-isoleucine-d10 with labeled l-alanine , reduces undesired background labeling to <1%.
Journal of biomolecular NMR  •  2009  |  View Paper
A-S of isoleucine , leucine and valine showed significant positive correlation to that of alanine (r = 0.59, r = 0.89, r = 0.77, respectively, during exercise, and r = 0.57, r = 0.65, r = 0.72, respectively, during pacing).
Japanese circulation journal  •  1993  |  View Paper
Substitution of alanine for arginine, valine, isoleucine , or either of the phenylalanines (but not glycine or histidine) within RGVHFIF resulted in loss of inhibitory activity.
Biochemistry  •  1992  |  View Paper
Alanine scan showed that substitution of each amino acid ranging from 58 to 62 with alanine had apparent impact on the hemolytic activity of rPLO, especially for the substitution of isoleucine 61 which caused almost complete loss of hemolytic activity of rPLO.
Veterinary microbiology  •  2016  |  View Paper
Under insulin-free conditions, isoleucine significantly inhibited glucose production when alanine was used as a glucogenic substrate in isolated hepatocytes.
American journal of physiology. Endocrinology and metabolism  •  2007  |  View Paper
It is suggested that the Ile to Ala mutation changes the probability for the formation of long-range interactions, which are present in the acid-denatured state of the wild-type protein.
Journal of molecular biology  •  2004  |  View Paper
However, whereas deletion of Ala 1 had minimal impact on toxin function, deletion of both Ala 1 and Ile 2 decreased insecticidal activity more than 70-fold.
Toxicon : official journal of the International Society on Toxinology  •  2002  |  View Paper
Replacement of the isoleucine with alanine reduced the affinity to all binding proteins to < 1%, suggesting a strong hydrophobic interaction.
Protein science : a publication of the Protein Society  •  1994  |  View Paper
Show More