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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Alanine
supplement:
Isoleucine
Research Papers that Mention the Interaction
“We found that a … amino acid substitution of alanine by phenylalanine at … or lysine by isoleucine at H93, significantly reduced the binding affinity for the TAG72 antigen by 12 and 20-fold, respectively, whereas the substitution of lysine by alanine at H73 reduced the binding affinity only two-fold.”
Framework residues 71 and 93 of the chimeric B72.3 antibody are major determinants of the conformation of heavy-chain hypervariable loops.“Thioflavin T assays indicate that substitution of isoleucine for alanine significantly reduces the rate and extent of fibrillization compared to the Aβ(25-40) and G37A peptides.”
“Following a careful analysis of known metabolic pathways we found that co-addition of perdeuterated forms of α-ketoisovalerate-d7, succinate-d4 and l-isoleucine-d10 with labeled l-alanine , reduces undesired background labeling to <1%.”
“A-S of isoleucine , leucine and valine showed significant positive correlation to that of alanine (r = 0.59, r = 0.89, r = 0.77, respectively, during exercise, and r = 0.57, r = 0.65, r = 0.72, respectively, during pacing).”
“Substitution of alanine for arginine, valine, isoleucine , or either of the phenylalanines (but not glycine or histidine) within RGVHFIF resulted in loss of inhibitory activity.”
“Alanine scan showed that substitution of each amino acid ranging from 58 to 62 with alanine had apparent impact on the hemolytic activity of rPLO, especially for the substitution of isoleucine 61 which caused almost complete loss of hemolytic activity of rPLO.”
Isoleucine 61 is important for the hemolytic activity of pyolysin of Trueperella pyogenes.“Under insulin-free conditions, isoleucine significantly inhibited glucose production when alanine was used as a glucogenic substrate in isolated hepatocytes.”
“It is suggested that the Ile to Ala mutation changes the probability for the formation of long-range interactions, which are present in the acid-denatured state of the wild-type protein.”
“However, whereas deletion of Ala 1 had minimal impact on toxin function, deletion of both Ala 1 and Ile 2 decreased insecticidal activity more than 70-fold.”
“Replacement of the isoleucine with alanine reduced the affinity to all binding proteins to < 1%, suggesting a strong hydrophobic interaction.”
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