Possible Interaction: Alanine and Insulin

“ Insulin also up-regulated the expression of GHR, IR, IGFBP3, and IGFBP4 mRNAs, and tended to prevent the transcript levels of IGF-I and IGFBP4 improved by ALA.”

“Recently, it has been suggested that α lipoic acid ALA ) improves insulin sensitivity by lowering triglyceride accumulation in nonadipose tissues via activation of skeletal muscle AMP-activated protein kinase (AMPK).”

“Moreover, the effect of ALA on insulin was duration-dependent (Pnon-linearity = 0.04).”

“The findings of the meta-analysis showed that ALA supplementation significantly reduced insulin (WMD: -0.64; CI: -1.287 to 0.004, P = .04), HOMA-IR (WMD: -0.48; 95% CI: -0.79 to -0.16; P = .002).”

“The results indicate that short‐term treatment with ALA can improve insulin sensitivity and plasma lipid profile possibly through amelioration of oxidative stress and chronic inflammatory reaction in obese patients with IGT.”

“Here, we demonstrate that its substitution with Ala markedly impairs insulin chain combination in vitro and blocks the folding and secretion of human proinsulin in a transfected mammalian cell line.”

“There was a close positive correlation between mean blood alanine and mean blood glucose (r = 0.79, p < 0.01), and a negative correlation of alanine with the amount of insulin infused (r =-0.72, p < 0.01).”

“Plasma insulin concentrations increased during L-alanine infusion in all groups to levels that were lower in the CaWL patients than in the CaWS patients and controls (P < 0.05).”

“We found that the exchange of serine to alanine at position 994 and at position 1023/25 increased insulin stimulated receptor autophosphorylation significantly (147% +/- 12% and 129% +/- 6% of control, p < 0.01, n = 7), while all other exchanges did not significantly alter insulin stimulated HIR autophosphorylation.”

“Net negative balances of alanine , methionine, glycine, threonine and asparagine (typical substrates for system A amino acid transport) also were decreased by insulin , whereas serine (another substrate for system A transport) shifted from a zero balance to net uptake.”

“Blood lactate, pyruvate and alanine concentrations were significantly higher with IP than IV insulin (P less than 0.05).”