Possible Interaction: Alanine and Glycylglycine

“Replacement of Gly2 in the myristoylation signal with Ala entirely inhibited the incorporation of [3H]-myristic acid into the fusion protein.”

“Inhibition of protein N-myristoylation by replacement of Gly2 with Ala or by the use of N-myristoylation inhibitor significantly inhibited membrane localization and the induction of cellular morphological changes, indicating that protein N-myristoylation plays critical roles in the cellular morphological changes induced by FMNL2 and FMNL3.”

“ Glycylglycine significantly inhibited absorption of several amino acid residues (aspartic acid + asparagine, serine, glutamic acid + glutamine, proline, alanine , phenylalanine, threonine and isoleucine) from the free amino acid mixture, whereas it significantly inhibited the absorption of only two (serine, glutamin acid + glutamine) from the peptide-containing partial casein hydrolysate.”

“In contrast, D‐alanine does not function as an acceptor substrate, but does noncompetitively inhibit the transfer of γ‐glutamyl groups to glycylglycine.”

“L-Serine, but not L-glycine or other amino acids tested, was found to be a competitive inhibitor of L-alanine uptake.”

“Both experimental and theoretical studies have been shown that the glycyl residue procudes a reduction of dimensions when it replaces in a tetrapeptide a residue with a beta-carbon atom such as the L-alanyl residue.”

“The l-alanine adding enzyme was inhibited by glycine and glycyl-glycine.”