Possible Interaction: Alanine and Glycine

“Substitution of the glycine at position 468 with an alanine or glutamic acid severely compromises protein activity and stability.”

“Substitution of glycine‐91 by site‐directed mutagenesis with either aspartate or alanine resulted in a significant decrease in transport activity of GLUT1 expressed in Xenopus oocytes.”

“By contrast, substitution of Ala for both Gly and Pro increases lateral diffusion mobility and accelerates internalization rate.”

“Replacement of Gly with Ala or Pro led to the decrease in antimicrobial activity.”

“A significant positive correlation was found between the serum levels of glycine and alanine , of glycine and serine, and of serine and alanine.”

“At saturating concentrations (30 mm) the rise time for glycine (0.26 ms) was 1.8‐fold faster than that for β‐alanine (0.47 ms) and 3.9‐fold faster than that for taurine (1.01 ms), indicating clear differences in the maximum opening rate between agonists.”

“ Alanine inhibited the Na(+)-dependent glycine uptake preferentially and the Na(+)- and Cl(-)-dependent glycine uptake represented > 95% of total uptake in the presence of 5 mM alanine.”

“Replacement of Arg or Asp by their stereoisomers or Gly by Ala resulted in a 100-1000-fold reduction in activity.”

“Via alanine , isoleucine, L-serine dehydratase/L-threonine deaminase and other proteins, AgNP-cit altered the metabolism of glycine , serine and threonine, cysteine and methionine, affecting oxidation and deamination, and ultimately leading to liver damage.”

“In ALAS, replacing the equivalent histidine, H282, with alanine reduces the catalytic efficiency for glycine 450-fold and decreases the slow phase rate for glycine binding by 85%.”