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Discover Supplement-Drug Interactions
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Last Updated: 2 years ago
supplement:
Alanine
supplement:
Glutathione
Research Papers that Mention the Interaction
“ Ala enhanced GSH reductase activity.”
Antioxidative activity of amino acids on tissue oxidative stress in human intestinal epithelial cell model.“Replacement of Cys16 with Ala increases the rate of GSH release from the active site causing a 10-fold decrease of affinity toward GSH.”
“Decreased GSH levels (P<.01) in the SHS‐colitis group approached to control levels when given ALA.”
Protective effect of alpha‐lipoic acid, aerobic or resistance exercise from colitis in second hand smoke exposed young rats“ ALA also increased the level of glutathione (GSH) and activities of superoxide dismutase (SOD) and glutathione S-transferase (GST) that were decreased in gastric damaged stomach tissues.”
“ ALA significantly inhibited the ability of CAR to induce: (1) the degree of acute inflammation, (2) the rise in MPx activity, (3) the increases of GST and iNOS activities and the amount of LPO and (4) the decreases of GPx, GR and SOD activities and the amount of GSH.”
“Mutation of Cys48 into Ala increased K(M)(GSH) 24-fold and decreased the binding energy of GSH by 1.5 kcal/mol.”
Modulating catalytic activity by unnatural amino acid residues in a GSH-binding loop of GST P1-1.
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