Possible Interaction: Alanine and Glutamine

“While concentrations of the BCAAs and alanine are rarely significantly altered, a marked decrease in glutamine concentration, particularly in skeletal muscle, is frequently observed.”

“Glutamate, glutamine , and aspartate either decrease or remain constant while alanine increases.”

“268, 16771-16780), glutamine is an inhibitor of the ammonia-dependent reaction catalyzed by both the Cys-1- ->Ala (C1A) and Cys-1-->Ser (C1S) mutants of AS-B. In the case of C1A, the inhibition pattern suggests that an abortive complex is formed.”

“The parenteral administration of a synthetic dipeptide containing glutamine and alanine decreased the muscular decrease of glutamine and alanine and increased the hepatic uptake of these two AA in a catabolic dog model.”

“For the regulation of TNF-α, l-glutamine, l-alanine and the combination of both … a congruent and exponentiated downregulating effect during endotoxemia, for the modulation of IL-6, l-glutamine … l-alanine featured opposite regulation leading to a canceling impact of each other when recombining both amino acids.”

“Biosynthetic networks linked with non‐essential amino acids alanine , serine, arginine, and proline are also significantly impacted by the use of glutamine as an alternate carbon source.”

“The efficiency of reverse transcription was severely impaired by nonconservative substitution of Gln with Ala , while conservative substitution of Gln with Asn resulted in an approximately 70% loss of activity, a value similar to that observed with the Y183F mutation.”

“There is also a positive correlation between alanine and glutamine and between leucine, isoleucine and glutamate.”

“ Glutamine uptake was markedly inhibited in the presence of L-alanine , L-asparagine, and L-serine.”

“Concurrently, splanchnic uptake of alanine and glutamine increased and muscle release of alanine ceased.”