Possible Interaction: Alanine and Glutamic Acid

“ Glutamic acid and aspartic acid increased several-fold less and alanine several-fold more than would be expected from their dietary concentrations.”

“Strikingly, replacement of Glu in the HEAT loop with Ala reduces efficiency by approximately 1000-fold.”

“Replacement of the glutamic acid with an alanine completely abolishes the inhibitory activity.”

“Substitution of glutamic acid at position 677 with either alanine or glutamine increased single-channel conductance, whereas the same substitutions at position 1387 resulted in a decrease in single-channel conductance with Ba2+ as the charge carrier.”

“A supplementation of the media with glutamic acid and the combination with alanine significantly accelerated the proliferation, migration and invasion of early stage melanoma cells, but not metastatic cells.”

“The substitution of glutamic acid , a large and negatively charged amino acid, with alanine , a small and non polar amino acid, in the interface of the α1- and β2-globin subunits might interfere with the transition between the oxy- and deoxyHb, and lead to Hb instability and hemolytic anemia.”

“Substitution of alanine for glutamic acid at residue 595 reduces fusion with epithelial cells, greatly enhances fusion with B cells and allows low levels of B cell fusion even in the absence of gL.”

“However, mutation of glutamic acid to alanine at position 69 of the fourth hypervariable region (HV4alpha) significantly increased the binding.”

“The uptake of glutamic acid was depressed by alanine , whereas glucose had a minor stimulatory effect Glibenclamide, leucine, arginine or galactose had no effect on the uptake of glutamic acid.”

“When radioactive dl-glutamic acid was present with l-alanine , the uptake of dl-glutamic acid increased dramatically following germination.”