Possible Interaction: Alanine and Glucose

“… ALA resulted in a significant increase … clearance rate (MCR) for glucose rose by about 50% (3.76 ml/kg/min = pre vs. 5.82 ml/kg/min = post, p < 0.05), … not show any significant change (3.57 ml/kg/min = pre vs. 3.91 ml/kg/min = post).”

“Moreover, serum levels of GLC decreased significantly in the ALA group compared to lack of changes in the placebo group (p = 0.011).”

“The glucose group had significantly higher concentrations of asparagine, glutamine, glycine, alanine , and lysine after treatment.”

“A bolus of alanine (0.2 g/kg) given intravenously increased the glucose production rate and blood glucose concentrations but blood lactate concentrations fell.”

“However, based on the data presented in the current paper, enteral glucose will enhance mucosal blood flow compared with enteral alanine ; however, the relevance of this observation to alanine specifically or that of a nitrogen source is unknown because a nitrogenous control was not included.”

“Conversions … alanine … glucose were also both significantly greater in NIDDM subjects (8.6 +/- 0.5 and 2.4 +/- 0.1 mumole/kg/min, respectively) than in ….2 +/- 0.4 and 1.8 +/- 0.1 mumol/kg/min, respectively, P less than 0.001 and P less than 0.025).”

“In the normal volunteers, infusion of glucose at 4 mg/kg/min suppressed total glucose production, the rate of gluconeogenesis from alanine , and the production of urea, despite an increase in the rate of release and uptake of alanine.”

“The concentrations of glucose and alanine decreased significantly.”

“Concomitante, large decreases in arterial glucose and SGO were observed during both alanine and glycerol administration.”

“Ingestion of a glucose load or a glucose-plus-beef meal caused an acute fall in the initially elevated plasma glucagon, alanine , proline, and lactate.”