Possible Interaction: Alanine and Glucagon

“We also show that the alanine codon GCG occurs >3-fold more often as second codon than in general, i.e. GCG was overrepresented.”

“We hypothesized that consumption of a specific combination of amino acids (arginine, alanine , and phenylalanine; A-mix) may be involved in secretion of glucagon , and when combined with exercise may promote fat catabolism.”

“The greater responses of glucagon to hypoglycaemia with alanine infusion were offset by recovery of eu- or hyperglycaemia.”

“ Glucagon increased the rate of urea synthesis by 35 +/- 11 mmol/hr (p less than 0.02) and decreased the alanine concentration by 0.22 +/- 0.06 mmol/l (p less than 0.01).”

“The secretory response of glucagon and insulin to oral alanine was blunted at 6 weeks post partum in the nondiabetic subjects.”

“The glucagon response to alanine was also increased threefold to fourfold in initial attacks.”

“These data (1) demonstrate that in … twelve to fourteen hours, glucagon at supraphysiblogic levels can … of gluconeogenesis from alanine and (2) indicate that this stimulatory effect of glucagon is exerted within the liver by … extracted alanine toward new glucose formation rather than by increasing the hepatic extraction of alanine.”

“And, although alanine stimulates secretion of glucagon , there is no consistent correlation between plasma alanine and glucose, or plasma alanine and glucagon concentrations during the early neonatal period.”

“Infused alanine caused increases in both plasma glucose and glucagon concentrations, as in the adult; the responses, however, were of small magnitude.”

“Bolus injection of alanine (1 mmol/kg) into a peripheral vein to six infants resulted in significant increments in glucagon (mean maximal, 128 pg/ml) as well as glucose and insulin.”

“ABSTRACT Intravenous administration of alanine (0.15 gm/kg) to normal women during labor resulted in umbilical vein and maternal glucagon levels which were 150–170% higher than in control subjects.”