Possible Interaction: Alanine and Ethanol

“ Alanine in arterial blood was reduced by approximately 25% after ethanol administration during exercise.”

“However, the inhibitory effects of ethanol were reduced by expression of an NR1 C0 domain deletion mutant (NR1Δ839–863), truncation mutant (NR1858stop), or a triple-point mutant (Arg to Ala , Lys to Ala, and Asn to Ala at 859–861) previously shown to significantly reduce calcium-dependent inactivation.”

“Prior chronic ethanol consumption depressed (p less than 0.05) placental uptake of AIB (38%), cycloleucine (45%), Ala (35%), Leu (25%), and Lys (34%).”

“As early as 1933, Widmark (Widmark, 1933) reported that when either glycine or alanine was co-administered with ethanol , lowered blood ethanol levels resulted as compared to those achieved when ethanol was administered. (”

“A pharmacokinetic interaction between the l-isomer of dl-MPH and ethanol has previously been shown to increase early exposure to d-MPH.”

“The diet with alcohol induced a sustained increase of branched chain amino acids persisting even after the postprandial phase with a decrease of alanine as compared to the diet without.”

“The most important factor modifying the response was intake of ethanol , which reduced the plasma concentrations of glucose, non-esterified fatty acids and alanine and raised that of lactate as well as the [β-hydroxybutyrate]/[acetoacetate] ratio.”

“Arterial alanine concentration decreased significantly, from 0.19 to 0.16 mmol, when alcohol was given but no net exchange by the brain could be observed.”

“ Ethanol (3% v/v present on both sides of the mucosa) decreased electrical potential difference (PD), short-circuit current (Isc) and inhibited active transport of Na+, 3-O-MG, andl-alanine.”

“Hence, it is suggested that CP, rather than its constituent amino acids such as alanine and proline, effectively takes part in enhancing the metabolism of ethanol as well as acetaldehyde.”