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Last Updated: 4 months ago

Possible Interaction: Alanine and Dexamethasone



Research Papers that Mention the Interaction

Several studies in the 1980s about the interorgan metabolism of amino acids showed that, in starvation and in the catabolic state, glutamine (GLN) is … influence of glucocorticoids on GLN release from skeletal muscle was demonstrated 1984 by Muhlbacher et al. 2 who showed that chronic administration of dexamethasone … alanine ….
Nutrition  •  2001  |  View Paper
Dexamethasone administered to healthy subjects in a daily dose of 3 mg over a four day period caused significant increases in alanine and methionine levels (26%) as well as a rise in arginine.
Diabete & metabolisme  •  1982  |  View Paper
Insulin at a physiological concentration (300 mU/l) and dexamethasone (0.001 mmol/l) had slight but significant effects on the incorporation rate of alanine into glucose and glycogen, respectively.
Scandinavian journal of clinical and laboratory investigation  •  1976  |  View Paper
Dexamethasone treatment in normal subjects resulted in a 40% rise in plasma alanine concentration which was directly proportional to the rise in basal glucagon.
In obese subjects, basal glucagon rose by 110% following dexamethasone , while the response to alanine increased fourfold.
The Journal of clinical investigation  •  1973  |  View Paper
Ser663 is invariantly conserved in all NHE3 proteins from several species, and the mutation of Ser663 to Ala blocks the effect of dexamethasone , demonstrating the importance of phosphorylation at Ser663.
American journal of physiology. Cell physiology  •  2005  |  View Paper
Dexamethasone resulted in a negative nitrogen balance, and produced decreases in the blood concentrations of glutamine (32.3%) and glutamate (25.3%) but an increase in the blood concentration of alanine (33.9%).
Clinical science  •  1991  |  View Paper
Likewise, dexamethasone accelerated the release of alanine by the lungs twofold (559 +/- 173 nmol/100 gm body weight/min in controls vs 1113 +/- 184 nmol/100 gm body weight/min in dexamethasone-treated rats; p less than 0.05).
Surgery  •  1990  |  View Paper
Dexamethasone resulted in negative nitrogen balance, and produced increases in the plasma concentrations of alanine (23.4%) and insulin (158%) but a decrease in the plasma concentration of glutamine (28.7%).
Clinical science  •  1990  |  View Paper