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Last Updated: 3 months ago

Possible Interaction: Alanine and Cysteine

supplement:

Alanine

supplement:

Cysteine

Research Papers that Mention the Interaction

Substitution of alanine for lysine, tryptophan, and cysteine reduced the peptide affinity ∼ 1- to 2.4-fold, whereas replacing leucine completely abolished binding.
Clinical Cancer Research  •  2007  |  View Paper
Replacement of the two cysteins with alanines in its active site results in loss of both enzymatic activities.
The Journal of Biological Chemistry  •  2003  |  View Paper
Since the replacement of the two cysteines (Cys97 and Cys100) in CD3-ε by alanines strongly inhibited pair formation, the existence of a Cys-X-X-Cys motif involved in protein-protein interactions is suggested.
The Journal of Biological Chemistry  •  1998  |  View Paper
Mitogenic activity is increased an additional 2.6 fold by substitution of cysteine-1 with alanine.
Biochemical and biophysical research communications  •  1994  |  View Paper
Substitution of the cysteine at position 580 by alanine resulted in impairment of interchain disulfide bridge formation; the mutagenized enzyme (C580A) was secreted from recombinant cells in the monomeric form and failed to assemble into dimers.
The Journal of biological chemistry  •  1991  |  View Paper
Proliferation of gastric cancer cells was promoted by cysteine , but inhibited by alanine and glutamic acid.
Journal of Translational Medicine  •  2015  |  View Paper
We also established that phenylarsine oxide-mediated inhibition of Top1 cleavage involved the two vicinal cysteines 504 and 505, as this effect was suppressed when cysteines were mutated to alanines.
Journal of Biological Chemistry  •  2007  |  View Paper
Substitution of cysteine 49 with alanine resulted in a semiactivated mutant enzyme with enzymatic properties partly resembling the activated form of microsomal glutathione transferase.
The Journal of Biological Chemistry  •  1997  |  View Paper
N‐Acetyl‐l‐cysteine (AC), alanine , β‐alanine, cysteine sulphinic acid (CSA), γ‐aminobutyric acid (GABA),d‐phenylalanine, phenylalanine, serine and taurine inhibited MeHg– cysteine uptake at 5°C.
Journal of applied toxicology : JAT  •  1996  |  View Paper
Cysteine inhibited it more efficiently than histidine, methionine, tryptophan, tyrosine or alanine under the conditions used.
Biochemical pharmacology  •  1991  |  View Paper
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