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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
Research Papers that Mention the Interaction
“However, mutating the Y652 residue to Ala enhances the blockade effect of capsaicin with an IC(50) of 4.11microM, whereas mutation of F656A does not significantly alter drug potency.”
Block effect of capsaicin on hERG potassium currents is enhanced by S6 mutation at Y652.“ Capsaicin also suppressed both basal and carbachol-stimulated 14C-catecholamine synthesis (IC50=10.6 and 26.4 μM, respectively) from [14C] tyrosine but not from l-3, 4-dihydroxyphenyl [3-14C] alanine ([14C] DOPA) as well as tyrosine hydroxylase activity (IC50=8.4 and 39.0 μM, respectively).”
Capsaicin inhibits catecholamine secretion and synthesis by blocking Na+ and Ca2+ influx through a vanilloid receptor-independent pathway in bovine adrenal medullary cells“ Alanine accumulation in rat hemidiaphragms is significantly inhibited by capsaicin in a dose-dependent pattern that produced maximal effect at 1 mM. 2.”
“min-1) reduced alanine absorption by 60% in sham control rats and by 20% in rats neonatally treated with capsaicin (P < 0.01).”
“In vitro, capsaicin significantly reduced uptake of alanine and proline by jejunal strips but had no effect on uptake of lysine.”
“In vivo, basal alanine absorption in rats neonatally treated with capsaicin was reduced by 35% below control.”
“In vitro, capsaicin reduced alanine uptake by intestinal strips in a dose-dependent manner.”
“Absorption of water, glucose and alanine was found to be significantly reduced in the presence of capsaicin.”
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