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Discover Supplement-Drug Interactions

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Last Updated: 3 years ago

Possible Interaction: Alanine and Calcitonin Gene-Related Peptide

Research Papers that Mention the Interaction

ECL2 seems especially important for CLR function; of the 16 residues so far examined in this loop, eight residues reduce the potency of CGRP at stimulating cAMP production when mutated to alanine.
Biochemical Society transactions  •  2012  |  View Paper
At 6 pM, CGRP decreased alanine absorption by 33%.
In in vivo experiments using the single-pass perfusion technique, intravenous infusion of CGRP (250-750 pmol/kg-min) reduced alanine absorption by 35-40%.
In vitro experiments using isolated jejunal strips showed that CGRP reduced alanine absorption in a dose-dependent manner.
Similarly, intracerebral injection of CGRP decreased alanine absorption, an effect which was reduced by vagotomy.
Regulatory Peptides  •  2000  |  View Paper