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Discover Supplement-Drug Interactions

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Last Updated: 2 years ago

Possible Interaction: Alanine and Baclofen

supplement:

Alanine

Research Papers that Mention the Interaction

Interestingly, our data also suggest that a residue within lobe II (Tyr366) interacts with the agonists in a closed form model of the binding domain, and its mutation into Ala converts the agonist baclofen into an antagonist.
The Journal of Biological Chemistry  •  2000  |  View Paper
It is concluded that baclofen at a high concentration inhibits the evoked release of Glu, Asp, Tau and Ala due to inhibition of the Ca(2+)-dependent fraction and also of the Ca(2+)-independent component in the case of Glu and Asp.
European journal of pharmacology  •  1992  |  View Paper
Baclofen (4 μM) inhibited the evoked release of endogenous 14C-labelled glutamate and aspartate by nearly 60%, that of endogenous14C-labelled threonine–serine–glutamine and alanine by 14–19%, but had no effect on that of endogenous14C-labelled GABA.
Canadian journal of physiology and pharmacology  •  1978  |  View Paper