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Last Updated: 5 months ago

Possible Interaction: Alanine and Aztreonam

supplement:

Alanine

Research Papers that Mention the Interaction

On the other hand, the kcat and Km values for oxyimino beta-lactams such as cefuroxime, ceftazidime, and aztreonam increased with increasing numbers of inserted alanines.
Biochemistry  •  1998  |  View Paper
This substitution of an Ala to a Gly at position 237 increases the hydrolysis of some beta-lactams, particularly aztreonam ; decreases the hydrolysis of benzylpenicillin, cephaloridine, and cefamandole, and decreases the susceptibility to clavulanic acid (fivefold increase in the 50% inhibitory concentration).
Antimicrobial agents and chemotherapy  •  1997  |  View Paper