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Last Updated: 3 months ago

Possible Interaction: Alanine and Aspartic Acid

supplement:

Alanine

supplement:

Aspartic Acid

Research Papers that Mention the Interaction

Exchange of aspartic acid at position 286 or 288 with alanine or asparagine decreased glucosyltransferase activity by about 5000-fold and completely blocked glucohydrolase activity.
The Journal of biological chemistry  •  1998  |  View Paper
Substitution of two aspartic acid residues with alanine at positions 54 and 59 abolished protease activity.
Molecular plant pathology  •  2011  |  View Paper
Substitution by alanine of the aspartic acid residue in the active site of both ICL domains completely abolishes their isochorismate lyase activity in vivo.
BioMetals  •  2011  |  View Paper
Substitution of this alanine residue to an aspartic acid abolished transactivation of both Myc-RP and Delila and severely reduced transactivation of Lc.
Planta  •  2007  |  View Paper
Glucose increased spore germination only slightly, regardless of pH, but enhanced germination when combined with alanine and aspartic acid.
Canadian journal of microbiology  •  1967  |  View Paper
The inhibition was competitively prevented by aspartic acid ; hence, because of the structural similarity of cysteic acid and aspartic acid, it appears that the enzyme system converting aspartic acid to fl-alanine was blocked by the inhibitor.
The Journal of biological chemistry  •  1946  |  View Paper
Substitution of the conserved aspartic acid at position 338 (TM VII) with alanine caused a loss of detectable receptor-evoked inhibition of cAMP generation, although this mutation did not appreciably affect ligand binding.
Molecular pharmacology  •  1997  |  View Paper
Conversely, for the L-isomer , a slight under-proportionality was detected in exposure with increasing doses of D ,L-MPH.
Biomedical chromatography : BMC  •  2004  |  View Paper
Whereas the folding of the mutated proteins was not seriously disrupted as judged by assembly into …, Golgi localization, and secretion of a soluble form of the enzyme, exchange of the highly conserved aspartic acid residues at position 356 … 358 with alanine or asparagine reduced enzyme activity to background levels.
Glycobiology  •  2001  |  View Paper
Substitution of aspartic acid117 and histidine260 by alanine in melanocortin 1 receptor resulted in a 4.75-fold decrease (Ki 4541 +/- 644 nM) and an 11-fold increase (Ki 84.29 +/- 4.53 nM), respectively, in the relative potency of 153N-6 for competitively inhibiting [125I]NDP-MSH binding.
Peptides  •  1996  |  View Paper
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