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“Neutralization of either aspartate to alanine caused a moderate reduction of the relative permeability for divalent cations and of the degree of outward rectification.”
The Journal of Biological Chemistry • 2002 | View Paper
“The substitution, in the human V2 vasopressin receptor, of the aspartate at position 136 by alanine leads to agonist‐independent activation of this mutant V2 receptor.”
The Journal of Biological Chemistry • 1999 | View Paper
“Turnover rates of the putative neurotransmitters aspartate , glutamate, and GABA) were 2–20‐fold higher than those of alanine and serine, and generally consistent with the proposed neurotransmitter functions for these amino acids.”
“We have prepared the stereoisomers of this inhibitor and shown that the L-isomer is only marginally more potent than the D-isomer as an inhibitor of the uptake of either L-glutamate or L-aspartate.”