Allen Institute for Artificial Intelligence logo

Discover Supplement-Drug Interactions

Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 3 months ago

Possible Interaction: Alanine and Ammonia





Research Papers that Mention the Interaction

Furthermore, after L-alanine oral load , significantly higher ammonia plasma levels were observed in cirrhotics than in controls.
The Italian journal of gastroenterology  •  1991  |  View Paper
G + A prevented the muscle ammonia increase by RT, whereas ALA and DIP augmented ammonia and glycogen concentrations in muscle.
Nutrients  •  2018  |  View Paper
In controls, ammonia increased 12.8-fold while glutamate and aspartate decreased by approximately 40% and glutamine and alanine raised by 37% and 93%, respectively; in hyperammonemic rats ammonia increased 6.9-fold while glutamate, glutamine and alanine were not significantly affected.
Biochimica et biophysica acta  •  1993  |  View Paper
Primarily, ammonia stimulated ureogenesis hence accelerating the deamination of alanine which led to the increased formation of pyruvate, lactate and glucose.
Biochimica et biophysica acta  •  1991  |  View Paper
Alanine , leucine, and glutamine significantly (P less than 0.01) increased ammonia release into mesenteric venous blood by 37, 42, and 106%, respectively, whereas threonine, serine, and glycine had no effect.
The American journal of physiology  •  1988  |  View Paper
When ammonia concentration was high, alanine concentration rose rapidly suggesting that alanine might serve as a storage depot for ammonia and also might provide an additional route for transport of glucose precursors (i.e., pyruvate) from the rumen.
Journal of dairy science  •  1977  |  View Paper
Alanine inhibited uncompetitively with respect to NADH (Ki=1.6 mM) and noncompetitively with respect to ammonia (Ki=2.0 mM) and pyruvate (Ki=3.0 mM).
Archives of Microbiology  •  2004  |  View Paper
In addition, the alanine mutant enzyme that is almost inactive in the deamination but significantly active in the amination was greatly stimulated by exogenously added ammonia , suggesting that proper binding of the substrate alpha-carboxyl group at Lys-68 is essential for catalysis.
The Journal of biological chemistry  •  1994  |  View Paper
In contrast, the inhibition of cytosolically generated alanine was less dramatic and averaged only 20% of the effect on ammonia production.
Journal of the American Society of Nephrology : JASN  •  1990  |  View Paper
Glutamine, glutamate, asparagine, aspartate, alanine , and serine levels decline concomitantly with ammonia accumulation.
Plant physiology  •  1986  |  View Paper
Show More