Possible Interaction: Alanine and Alanylglutamine

“In addition, ALA-GLN dipeptide supplementation produced a marginal increase in plasma levels of alanine , glutamine and citrulline [2].”

“Administration of ALA-GLN dipeptide increased the plasma concentration of alanine (p = .004), glutamine (p < .001) and citrulline (p = .006).ConclusionsWe found an early depletion of plasma AAs’ concentration which partially recovered at day 6, which was unaffected by the route of nutrition.”

“Infusion of alanylglutamine significantly (P less than .01) increased arterial plasma concentrations of free alanine (260 +/- 31 v 330 +/- 38 mumol/L) and free glutamine (620 +/- 66 v 764 +/- 65 mumol/L) when compared with the baseline period.”

“We conclude that the infusion of alanylglutamine markedly influences the hepatic metabolism of glutamine and alanine , probably via the increased arterial and portal levels of glutamine and alanine.”

“… alanylglutamine significantly increased the … glutamine and alanine (from 0.8 +/- 0.2 to 3.8 +/- 0.6 and from 3.0 +/- 0.4 to 7.5 +/- 0.7 ….min respectively; P less than .01) and did not significantly change the intestinal uptake of glutamine and the release of alanine.”

“This study demonstrates that during short-term administration of alanylglutamine or of the corresponding amino acids the nitrogen release from the hindlimb of the anaesthetized post-operative dog via alanine and glutamine is reduced.”

“ AlaGln supplementation of PD fluid altered levels of specific metabolites, including increases in alanine and glutamine but not glutamate, and reduced levels of small molecule indicators of oxidative stress, such as methionine sulfoxide.”