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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
Research Papers that Mention the Interaction
“ Quinidine induced a marked increase to give a mean peak concentration of ajmaline which increased from 0·018 μg ml−1 after a single administration to 0·141 μg ml−1 in combination with quinidine.”
“The area under the ajmaline concentration‐time curves was increased 10 to 30‐fold by the concurrent administration of quinidine.”
“The results indicate the existence of a significant interaction between oral ajmaline and quinidine.”
Quinidine‐induced rise in ajmaline plasma concentration“Concurrent oral administration of 10 mg/kg of quinidine markedly increased the plasma concentration of ajmaline at a dose of 2 mg/kg.”
“Furthermore, quinidine delayed the elimination rate of ajmaline from the perfused rat liver.”
“In fact, when ajmaline was administered into the intestinal loop, its concentration in mesenteric venous plasma increased approximately 5-fold by the combination with quinidine.”
“The availability of ajmaline after oral dose showed an increase from 13% to nearly 100% by the presence of quinidine , which suggests a change in the presystemic clearance of ajmaline.”
“These results indicate that quinidine prevents presystemic elimination of ajmaline in the intestine and liver, and increases the systemic availability of ajmaline.”
Mechanisms of pharmacokinetic interaction between ajmaline and quinidine in rats.
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