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Possible Interaction: Agmatine and Nitric Oxide



Research Papers that Mention the Interaction

Agmatine holds the key to prevent the toxic effects associated with induction of NO synthesis by its ability to inhibit inducible nitric oxide synthase (iNOS).
Pharmacological research  •  2004  |  View Paper
Therefore, agmatine appears to act directly on endothelial cells to increase the synthesis of nitric oxide , a vasodilatory substance.
These results suggest that agmatine can bind to a cell surface imidazoline receptor on endothelial cells and can stimulate nitric oxide production by increasing cytosolic calcium.
Proceedings of the Association of American Physicians  •  1997  |  View Paper
Moreover, AGM decreased renal levels of malondialdehyde (MDA), nitric oxide ( NO ), tumor necrosis factor‐alpha (TNF‐&agr;), interleukin 1‐beta (IL‐1&bgr;), neutrophil gelatinase‐associated lipocalin (NGAL), inducible nitric oxide synthase (iNOS), nuclear factor kappa B (NF‐&kgr;B) and myeloperoxidase (MPO).
Life sciences  •  2018  |  View Paper
Agmatine inhibited the activation of nuclear factor‐κB and ameliorated the immunoexpression of inducible nitric oxide synthetase.
Journal of biochemical and molecular toxicology  •  2018  |  View Paper
agmatine treatment significantly induced vascular endothelial growth factor (VEGF), VEGF receptor 2 (Flk-1/KDR or VEGFR2), phosphatidylinositol …/protein kinase B (also known as PKB, PI3K downstream effector protein), endothelial nitric oxide synthase (eNOS) nitric oxide (NO; product by eNOS) and intercellular adhesion …) expressions during bEnd.3 cells migration.
Life sciences  •  2013  |  View Paper
Importantly, agmatine decreased total nitric oxide (NO) and pro-inflammatory cytokine, tumor necrosis factor-alpha (TNF-α).
Inflammopharmacology  •  2013  |  View Paper
NO production was decreased in CECs after similar insult and was increased by agmatine treatment.
Neurological research  •  2007  |  View Paper
Administration of a 100-mg/kg/day dose of agmatine reduced the NO levels to those measured in controls.
Journal of neurosurgery. Spine  •  2006  |  View Paper
These results suggest the possible involvement of inducible nitric oxide system in potentiating effects of agmatine on morphine-induced place preference.
Neuroscience Letters  •  2006  |  View Paper
These results show that agmatine inhibits the production of nitric oxide by decreasing the activity of NOS‐2 in macrophages and astroglial cells by decreasing the levels of NOS‐2 protein.
Annals of the New York Academy of Sciences  •  2003  |  View Paper
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