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Discover Supplement-Drug Interactions
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Last Updated: 5 years ago
supplement:
Agmatine
drug:
Nitric Oxide
Research Papers that Mention the Interaction
“ Agmatine holds the key to prevent the toxic effects associated with induction of NO synthesis by its ability to inhibit inducible nitric oxide synthase (iNOS).”
Vascular regulation by the L-arginine metabolites, nitric oxide and agmatine.“Therefore, agmatine appears to act directly on endothelial cells to increase the synthesis of nitric oxide , a vasodilatory substance.”
“These results suggest that agmatine can bind to a cell surface imidazoline receptor on endothelial cells and can stimulate nitric oxide production by increasing cytosolic calcium.”
“Earlier, we showed that the endogenous neurotransmitter agmatine in micromolar concentrations via α2-AR activates the nitric oxide ( NO ) synthesis, enhancing the Ca2+ pumping into sarcoplasmic reticulum (SR).”
α2-Adrenoceptor signaling in cardiomyocytes of spontaneously hypertensive rats starts to impair already at early age.“Moreover, AGM decreased renal levels of malondialdehyde (MDA), nitric oxide ( NO ), tumor necrosis factor‐alpha (TNF‐&agr;), interleukin 1‐beta (IL‐1&bgr;), neutrophil gelatinase‐associated lipocalin (NGAL), inducible nitric oxide synthase (iNOS), nuclear factor kappa B (NF‐&kgr;B) and myeloperoxidase (MPO).”
“ Agmatine inhibited the activation of nuclear factor‐κB and ameliorated the immunoexpression of inducible nitric oxide synthetase.”
“… agmatine treatment significantly induced vascular endothelial growth factor (VEGF), VEGF receptor 2 (Flk-1/KDR or VEGFR2), phosphatidylinositol …/protein kinase B (also known as PKB, PI3K downstream effector protein), endothelial nitric oxide synthase (eNOS) nitric oxide (NO; product by eNOS) and intercellular adhesion …) expressions during bEnd.3 cells migration.”
“Importantly, agmatine decreased total nitric oxide (NO) and pro-inflammatory cytokine, tumor necrosis factor-alpha (TNF-α).”
“ NO production was decreased in CECs after similar insult and was increased by agmatine treatment.”
“Administration of a 100-mg/kg/day dose of agmatine reduced the NO levels to those measured in controls.”
“These results suggest the possible involvement of inducible nitric oxide system in potentiating effects of agmatine on morphine-induced place preference.”
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